67. ORTHOTOPIC LIVER TRANSPLANTATION IN CHILDREN

Ascites after orthotopic liver transplantation in children.

Ascites is a poorly understood postoperative complication of orthotopic liver transplantation (OLT). It is associated with additional morbidity and can prolong hospitalization considerably. The incidence, the factors predictive of occurrence and the etiology of this complication are not known. The charts of 118 patients with 138 OLT were analyzed according to the following criteria: ascites las...

Orthotopic Liver Transplantation

Orthotopic Liver Transplantation

A 7-year-old girl with progressive ataxia, spasticity, supranuclear ophthalmoplegia, and sea-blue histiocytes in her bone marrow underwent orthotopic liver transplantation for hepatocellular carcinoma. After an initial period of stabilization, she has shown progression of neurologic symptoms with recurrence of storage material in the transplanted liver. Pediatrics 1986;77:104-106; lipidosis, se...

Orthotopic Liver Transplantation in Children With Hepatic-Based Metabolic Disease.

S UCCESSFUL orthotopic liver transplan-tation provides a unique opportunity to study systemic effects of hepatic-based metabolic disease and to potentially provide a cure for previously often fatal illnesses. From May 9, 1981 through the next 12 months, 23 patients received orthotopic liver transplants. Children ranged from 7.5 months to 18 years of age. Each patient re-::eived cyclosporin-A (C...

Extrahepatic metabolism of sevoflurane in children undergoing orthotopic liver transplantation.

BACKGROUND Sevoflurane is metabolized by cytochrome P450 and produces inorganic fluoride. The anhepatic phase of liver transplantation provides a useful tool to study the extrahepatic metabolism of drugs. The authors therefore studied the extrahepatic metabolism of sevoflurane by measuring the fluoride production in children receiving sevoflurane solely during the anhepatic phase of orthotopic ...